| Scientific Organizers: |
J.-R. Chazottes CPHT, Ecole Polytechnique, Palaiseau, France P. Collet CPHT, Ecole Polytechnique, Palaiseau, France R. Lima CPT, Luminy, Marseille, France D. Thieffry ESIL/LBDM, Luminy, Marseille, France E. Ugalde IICO-UASLP, San Luis Potosí, México |
Introduction
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Molecular biology, including genomics and, more recently, functional genomics has provide
a wealth of information on the molecular mechanisms at the basis of many crucial biological
phenomena, such as cell proliferation, cell differentiation, various types of cancer, etc.
In most case, sets molecular species and numerous cross-interactions have been identified.
A throughout understanding of the spatial-temporal behavior of these complex networks requires
the development of appropriate integrative approaches, at the interface between various
experimental and theoretical disciplines. The main aim of the present gathering precisely
consists in promoting cross-disciplinary projects involving physicists, biologists, computer
scientists and mathematicians. During a whole month, these researchers will be able to focus
on specific biological questions, to share and discuss relevant concepts and methodologies,
to finally shape more ambitious international projects. From a biological perspective, a
particular emphasis will be put on the analysis of
* intra-cellular gene networks controlling cell proliferation and differentiation * inter-cellular networks, in particular in relation with the development of a proper immune response or in the context of cell differentiation and pattern formation during embryonic development. From a theoretical perspective, one can distinguish three main approaches to be encompassed during the Cuernavaca gathering, each based on a different formal representation: * a graph-based representation of regulatory networks (covering the two biological levels mentioned above); * (ii) a qualitative dynamical formalization of these regulatory networks in terms of logical equations; * a fully quantitative dynamical formalization in terms of differential equations and coupled map lattices. A particular emphasis will be put on connecting ("mapping") these different approaches with (on) each other, as well as on the evaluation of the different kinds of data available, enabling the building of useful dynamical models, their parameterization, as well as the validation of their outcome (biological predictions). While working and confronting views on specific modelling studies, we will also address general issues concerning the "modularity" of regulatory networks (i.e., the possibility of breaking large networks in meaningful and functional subsystems), the dynamical coupling of related cross-regulatory modules, and the related problem of synchronization. Indeed, the phenomenon of synchronization has recently received a great attention from the mathematical, physical, biological and practical point of view. Synchronization roughly means the ``same behavior in time'' of two or more differen subsystems of a large system. This phenomenon has been quite well understood on the mathematical level for master-slave systems or skew-product dynamical systems, that is in presence of a unidirectional coupling. This phenomenon possibly plays an important role in the regulation of gene networks that can be modelled as (extended) dynamical systems. Finally, a series of computer implementations of modelling and simulations methods, as well as the related standardization issues (model and dynamics descriptions) will be also analyzed and discussed extensively. |
Participants
| V. Afraimovich | IICO-UASLP | July 20th - August 16th |
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| F. Briolle | CPT-CNRS, Marseille, France | July 7 - August 8th | ||
| J.-R. Chazottes | CPHT-Ecole Polytechnique, Palaiseau, France | July 15th - August 15th | ||
| C. Chouiya | ESIL/LBDM, Marseille, France | July 20th - August 16th | ||
| G. Cocho | Instituto de Fisica, UNAM | July 20th - August 16th |
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| P. Collet | CPHT-Ecole Polytechnique, Palaiseau, France | July 20th - August 12 | ||
| J. Diaz | Facultad de Ciencias, UAEM | July 20th - August 16th |
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| B. Fernandez | CPT-CNRS, Marseille, France | July 22nd - August 13th | ||
| D. Gabrielli | L'Aquila, Italia | July 17th - August 24th | ||
| A. Gonzales | LGPD-IBDM, Marseille, France | July 18th - August 20th | ||
| P. Guiraud | CPT-CNRS, Marseille, France | July 20th - August 31st | ||
| R. Lima | CPT-CNRS, Marseille, France | July 20th - August 31st | ||
| L. Marques Porto | Univ. Fed. Santa Catarina, Florianópolis, Brazil | July 18th - August 17th | ||
| G. Martinez | Centro de Cienicas Fisicas, Cuernavaca, UNAM | July 20th - August 16th |
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| A. Meyronenc | CPT-CNRS, Marseille, France | July 18th - August 25th | ||
| A. Morante* | Facultad de Ciencias, UASLP | July 20th - August 16th |
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| M. Mueller | Fac de Ciencias UAEM | July 20th - August 16th |
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| P. Parmananda | Facultad de Ciencias, UAEM | July 20th - August 16th |
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| R. Rechtman | Centro de Investigacion en Energia, Temixco, UNAM | July 20th - August 16th |
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| L. Sanchez | CSIC, Madrid, Spain | July 23rd - August 14th | ||
| A. Sarmiento | Instituto de Matematicas, Cuernavaca, UNAM | July 20th - August 16th |
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| E. Simão | Univ. Fed. Santa Catarina, Florianópolis, Brazil | July 18th - August 17th | ||
| D. Thieffry | ESIL/LBDM, Marseille, France | July 20th - August 16th | ||
| E. Ugalde | IICO, UASLP | July 20th - August 16th |
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Please, visit this site regularly as dates and participants may change. We will do our best to keep the information up to date. If you may have interest in participate in this gathering, please contact CiC. |
